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KMID : 0383919700070000171
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Report of National Institute of Health
1970 Volume.7 No. 0 p.171 ~ p.176
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Studies on the Lactobacillus Products for Pharmaceutical Use
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Abstract
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In order to evaluate the Lactobacillus products for pharmaceutical use, it´s microbial viabilities of the products play the very important role for quality control of this field of drugs. On this point of view, a study was challenged and observed to find out especially the viability of Strc. faecalis-Y, L. sporogenes-I and each of both strains absorbed and heat dried with starch-lactose powder, under different storage temperature conditions during 6 months respectively.
Accessorily microbiological characterization of Strc. faecalis-Y and L. sporogenes-I were isolated and tested from products employed and bacteriolgical comparison of counting media were also accompanied through the experiment.
The study reported here can provide follwing results;
1. It shows that L. sporogenes-I products has less viability than that of Strc. Faecalis-Y products among tested samples.
2. The sample which were prepared with Strc.faecalis-Y and L. sporogene & I absorbed and heat dried with starch-lactose powder showed remarkable decreasing of viability to than that of it´s complet products made of with many other components.
3. According to the viability test to tablet product of L. sporogenes-I, under storage in room temperature condition during 6 months, the original popullation of 50 ⅹ 10^(6)/g organisms were decreased to 10 ⅹ 10^(4)/g.
4. The viability specially prepared with L. sporogenes-I which were absorbed and heat dried with starchlactose powder, under storage in room temperature condition during 6 months, 15 ⅹ 10^(8)/g of original poullation of othe organisms were decreased to 18 ⅹ 10^(7)/g.
5. To the tablet product of Strc. faecalis-Y which were storaged under room temperpature during 6 months, the original popullation of 10 ⅹ 10^(7)/g organisms were markedly decreased to 76 ⅹ 10^(3)/g.
6. To the sample which were prepared with Strc. faecalis-Y absorbed and heat dried with starchlactose powder also storaged under room temperature condition during 6 months, 20 ⅹ 10^(7)/g of original popullation of the orgoanisms were decreased to 96 ⅹ 10^(4)/g
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